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Exposure to bifenthrin disrupts the development of testis in male Sebastiscus marmoratus

LI Jinshou,  LUO Fen,  LIU Liyue,  RUAN Junfeng,  WANG Nannan

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文章导航 > Acta Oceanologica Sinica  > 2017 >  36(2): 57-61
李进寿, 罗芬, 刘立跃, 阮俊峰, 王楠楠. 联苯菊酯暴露对雄性褐菖鲉精巢发育的干扰[J]. 海洋学报英文版, 2017, 36(2): 57-61. doi: 10.1007/s13131-017-1001-7
引用本文: 李进寿, 罗芬, 刘立跃, 阮俊峰, 王楠楠. 联苯菊酯暴露对雄性褐菖鲉精巢发育的干扰[J]. 海洋学报英文版, 2017, 36(2): 57-61. doi: 10.1007/s13131-017-1001-7
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LI Jinshou, LUO Fen, LIU Liyue, RUAN Junfeng, WANG Nannan. Exposure to bifenthrin disrupts the development of testis in male Sebastiscus marmoratus[J]. Acta Oceanologica Sinica, 2017, 36(2): 57-61. doi: 10.1007/s13131-017-1001-7
Citation: LI Jinshou, LUO Fen, LIU Liyue, RUAN Junfeng, WANG Nannan. Exposure to bifenthrin disrupts the development of testis in male Sebastiscus marmoratus[J]. Acta Oceanologica Sinica, 2017, 36(2): 57-61. doi: 10.1007/s13131-017-1001-7
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联苯菊酯暴露对雄性褐菖鲉精巢发育的干扰

doi: 10.1007/s13131-017-1001-7

  • 宁德师范学院生物系

基金项目: The Natural Science Foundation of Fujian Province under contract No. 2013N0029; the Provincial Colleges and Universities in Fujian Province Department of Education Scientific Research Fund under contract No. JK2012061.

Exposure to bifenthrin disrupts the development of testis in male Sebastiscus marmoratus

  • Department of Biology, Ningde Normal University, Ningde 352100, China

    摘要
  • 摘要: 联苯菊酯是广泛应用于农业、园林及住宅等领域的拟除虫菊酯类杀虫剂，然而有关联苯菊酯对鱼类生殖毒性的研究却很少。本研究旨在探讨联苯菊酯对褐菖鲉精巢发育的影响及其相关机制。褐菖鲉在以浓度分别为1、10、100 ng·L-1的联苯菊酯暴露50 d后，各暴露组精巢成熟精子数量均较对照组出现大量减少并在精巢小叶中积累大量的处于不同发育时期的未成熟精细胞。精巢17-β雌激素与雄激素水平在联苯菊酯暴露后均出现显著下降。精巢在联苯菊酯暴露后caspase-3活性与暴露药物呈剂量依赖性上升，TUNEL分析表明联苯菊酯的暴露导致精巢生殖细胞的凋亡，这可能是抑制精巢精子发生的主要原因。
    Abstract: Bifenthrin (BF) is a pyrethroid insecticide that is widely used in agriculture, horticulture, and for residential purposes. However, few studies addressing the reproductive toxicity of BF on fishes are available. The present study was conducted to investigate the effects of BF on testicular development in Sebastiscus marmoratus and to gain insight into its mechanism. After exposure to 1, 10 and 100 ng/L BF for 50 days, there was a reduced number of mature sperm and an abundance of the late stages of spermatocysts in the testes. The levels of 17β-estradiol and testosterone were decreased significantly after BF exposure. The activity of caspase-3 was increased in a dose-dependent manner after BF exposure, TUNEL assay indicated that BF exposure resulted in the occurrence of apoptosis in the testes, which might be main reason for the inhibition of spermatogenesis.
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出版历程
  • 收稿日期:  2016-08-22
  • 修回日期:  2016-10-13

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