Based on the linear wave theory and model experiment results, the wave-current force coefficients for isolated pile are investigated, using Morison's formula to calculate the wave-current force.A formula is presented for determining the relative coefficients of the drag, in which the feature value of the wave-current field is proposed and used as an important parameter.According to the maximum wave-current force measured in the experiment, the coefficients of the drag force and inertia force are determined by statistical method of two-variable regression so that both of them are fitted in optimum.