The chief purpose of the research was to understand the physiological function change regularity, performance and adaptability of the human body living and working under high pressure for prolonged time. In January 1989, 4 naval divers entered the habital of NMRI's 500 msw saturation diving system after a series of adaptive diving training. The breathing mixture was helium-oxygen. After 55 h compression (including intermediate stages) the 350 msw depth was reached, where the divers lived and worked for 72 h 10 min. No sign of discomfort or significant HPNS was found in the 4 divers. The second and third day of the saturation exposure, the divers carried out 370 msw dry and wet chamber excursion diving 2 man-time each, the divers effectively carried out operational work under water, the total excursion time was 1 h each excursion dive.